View source for 2kvf


==Structure of the three-Cys2His2 domain of mouse testis zinc finger protein==
<StructureSection load='2kvf' size='340' side='right'caption='[[2kvf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kvf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvf OCA], [https://pdbe.org/2kvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvf RCSB], [https://www.ebi.ac.uk/pdbsum/2kvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZBT32_MOUSE ZBT32_MOUSE] DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor (By similarity). Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells.<ref>PMID:11279021</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chen C]]
[[Category: Chou C-C]]
[[Category: Lou Y-C]]