View source for 2kyj


==Structure of the scorpion toxin U1-Liotoxin-Lw1a==
<StructureSection load='2kyj' size='340' side='right'caption='[[2kyj]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Liocheles_australasiae Liocheles australasiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KYJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kyj OCA], [https://pdbe.org/2kyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kyj RCSB], [https://www.ebi.ac.uk/pdbsum/2kyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kyj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TXS2B_HORWA TXS2B_HORWA] Affects the activity of both ryanodine-sensitive calcium-release channels RyR1 and RyR2 with high potency. At lower concentrations the toxin increases full openings of the RyRs, and at higher concentrations it inhibits full openings and induce openings to subconductance levels and reduces the number of full conductance openings. The different actions may be attributed to the toxins binding at different sites on the RyRs, with binding at a high-affinity site mediating the increase in full openings and the induction of subconductance states evoked upon binding to a lower-affinity site. Insect-selective toxin that provokes a dose-dependent contractile paralysis in crickets and blowfly larvae, followed by death.<ref>PMID:21670253</ref> <ref>PMID:23671114</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Liocheles australasiae]]
[[Category: Alewood PF]]
[[Category: Hill J]]
[[Category: King GF]]
[[Category: Smith J]]