View source for 2kzy


==Solution NMR structure of the ZNF216 A20 zinc finger==
<StructureSection load='2kzy' size='340' side='right'caption='[[2kzy]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kzy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [https://pdbe.org/2kzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [https://www.ebi.ac.uk/pdbsum/2kzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZFAN5_RAT ZFAN5_RAT] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity).
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Garner TP]]
[[Category: Layfield R]]
[[Category: Long JE]]
[[Category: Searle MS]]