View source for 2l3j


==The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read out of the minor groove==
<StructureSection load='2l3j' size='340' side='right'caption='[[2l3j]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3j OCA], [https://pdbe.org/2l3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3j RCSB], [https://www.ebi.ac.uk/pdbsum/2l3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RED1_RAT RED1_RAT] Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis.<ref>PMID:20501795</ref> <ref>PMID:16472753</ref> <ref>PMID:20946981</ref> 

==See Also==
*[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Allain FH-T]]
[[Category: Oberstrass FC]]
[[Category: Stefl R]]