View source for 2l3n


==Solution structure of Rap1-Taz1 fusion protein==
<StructureSection load='2l3n' size='340' side='right'caption='[[2l3n]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3n OCA], [https://pdbe.org/2l3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3n RCSB], [https://www.ebi.ac.uk/pdbsum/2l3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TAZ1_SCHPO TAZ1_SCHPO] Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis.[https://www.uniprot.org/uniprot/RAP1_SCHPO RAP1_SCHPO] Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE). Unlike yeast, exhibits no effect in transcription regulation.<ref>PMID:11676924</ref> <ref>PMID:11676925</ref> <ref>PMID:19948484</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Chen Y]]
[[Category: Hu H]]
[[Category: Lei M]]
[[Category: Wang F]]
[[Category: Zhou ZR]]