View source for 2l4f


==NMR structure of the UBA domain of S. cerevisiae Dcn1 bound to ubiquitin==
<StructureSection load='2l4f' size='340' side='right'caption='[[2l4f]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4f OCA], [https://pdbe.org/2l4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4f RCSB], [https://www.ebi.ac.uk/pdbsum/2l4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCN1_YEAST DCN1_YEAST] Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes.<ref>PMID:15988528</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Burschowsky D]]
[[Category: Mattle D]]
[[Category: Peter M]]
[[Category: Rudolf F]]
[[Category: Wider G]]