View source for 2lau


==Solution structure of the THAP-zinc finger domain 1-81 from the cell growth suppressor human THAP11 protein==
<StructureSection load='2lau' size='340' side='right'caption='[[2lau]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lau OCA], [https://pdbe.org/2lau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lau RCSB], [https://www.ebi.ac.uk/pdbsum/2lau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lau ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THA11_HUMAN THA11_HUMAN] Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Campagne S]]
[[Category: Durand J]]
[[Category: Gervais V]]
[[Category: Milon A]]