View source for 2lbu


==HADDOCK calculated model of Congo red bound to the HET-s amyloid==
<StructureSection load='2lbu' size='340' side='right'caption='[[2lbu]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lbu]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR,  models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CGO:SODIUM+3,3-(1E,1E)-BIPHENYL-4,4-DIYLBIS(DIAZENE-2,1-DIYL)BIS(4-AMINONAPHTHALENE-1-SULFONATE)'>CGO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbu OCA], [https://pdbe.org/2lbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lbu RCSB], [https://www.ebi.ac.uk/pdbsum/2lbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lbu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HETS_PODAS HETS_PODAS] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.<ref>PMID:1886611</ref> <ref>PMID:8224826</ref> <ref>PMID:9275200</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Podospora anserina]]
[[Category: Aguzzi A]]
[[Category: Bockmann A]]
[[Category: Ernst M]]
[[Category: Hornemann S]]
[[Category: Meier BH]]
[[Category: Schutz AK]]
[[Category: Soragni A]]