View source for 2lbw


==Solution structure of the S. cerevisiae H/ACA RNP protein Nhp2p-S82W mutant==
<StructureSection load='2lbw' size='340' side='right'caption='[[2lbw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lbw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbw OCA], [https://pdbe.org/2lbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lbw RCSB], [https://www.ebi.ac.uk/pdbsum/2lbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lbw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NHP2_YEAST NHP2_YEAST] Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Essential for growth. Directly binds H/ACA snoRNAs.<ref>PMID:11433018</ref> <ref>PMID:9843512</ref> <ref>PMID:9848653</ref> 

==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Chanfreau G]]
[[Category: Chim N]]
[[Category: Ding Y]]
[[Category: Feigon J]]
[[Category: Fernandez CF]]
[[Category: Koo B]]
[[Category: Park C]]