View source for 2lcm


==NMR structure of S3-4 peptide==
<StructureSection load='2lcm' size='340' side='right'caption='[[2lcm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lcm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LCM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lcm OCA], [https://pdbe.org/2lcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lcm RCSB], [https://www.ebi.ac.uk/pdbsum/2lcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lcm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAC1B_HUMAN CAC1B_HUMAN] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Darbon H]]
[[Category: De waar M]]
[[Category: Douzi B]]