View source for 2lfh


==Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A==
<StructureSection load='2lfh' size='340' side='right'caption='[[2lfh]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lfh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfh OCA], [https://pdbe.org/2lfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfh RCSB], [https://www.ebi.ac.uk/pdbsum/2lfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ID3_HUMAN ID3_HUMAN] ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors.<ref>PMID:8437843</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Acton TB]]
[[Category: Eletsky A]]
[[Category: Everett JK]]
[[Category: Janjua H]]
[[Category: Kohan E]]
[[Category: Montelione GT]]
[[Category: Szyperski T]]
[[Category: Wang D]]
[[Category: Xiao R]]