View source for 2ljc


==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
<StructureSection load='2ljc' size='340' side='right'caption='[[2ljc]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Taiwan/70061/2006) Influenza B virus (B/Taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [https://pdbe.org/2ljc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [https://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B4UQM4_9INFB B4UQM4_9INFB] [https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]

==See Also==
*[[M2 protein|M2 protein]]
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</StructureSection>
[[Category: Influenza A virus H3N2]]
[[Category: Large Structures]]
[[Category: Chou JJ]]
[[Category: Oxenoid K]]
[[Category: Pielak RM]]