View source for 2lk2


==Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, Northeast Structural Genomics Consortium Target HR4411B==
<StructureSection load='2lk2' size='340' side='right'caption='[[2lk2]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LK2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lk2 OCA], [https://pdbe.org/2lk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lk2 RCSB], [https://www.ebi.ac.uk/pdbsum/2lk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lk2 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TGIF1_HUMAN TGIF1_HUMAN] Septopreoptic holoprosencephaly;Semilobar holoprosencephaly;Lobar holoprosencephaly;Alobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly;Microform holoprosencephaly. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TGIF1_HUMAN TGIF1_HUMAN] Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Acton TB]]
[[Category: Ciccosanti C]]
[[Category: Cort JR]]
[[Category: Everett JK]]
[[Category: Hamilton K]]
[[Category: Kennedy MA]]
[[Category: Montelione GT]]
[[Category: Ramelot TA]]
[[Category: Shastry R]]
[[Category: Xiao R]]
[[Category: Yang Y]]