View source for 2lke


==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==
<StructureSection load='2lke' size='340' side='right'caption='[[2lke]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lke OCA], [https://pdbe.org/2lke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lke RCSB], [https://www.ebi.ac.uk/pdbsum/2lke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lke ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
== Function ==
[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

==See Also==
*[[Integrin 3D structures|Integrin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Amalraj M]]
[[Category: Bhattacharjya S]]
[[Category: Chua GL]]
[[Category: Tan SM]]
[[Category: Tang XY]]