View source for 2lnf


==Neurotensin 40 structures in DMPC/CHAPS(q=0.25) bicelle pH 5.5 & 298K. NMR data & Structures==
<StructureSection load='2lnf' size='340' side='right'caption='[[2lnf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnf OCA], [https://pdbe.org/2lnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnf RCSB], [https://www.ebi.ac.uk/pdbsum/2lnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEUT_HUMAN NEUT_HUMAN] Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
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== Publication Abstract from PubMed ==
Neurotensin (NT) is an endogenous tridecapeptide neurotransmitter that shows multiple biological function in central and peripheral nervous systems. Gangliosides are glycosphingolipids, most abundant in the plasma membrane of nerve cells. Here we investigate the change of neurotensin solution structure induced by isotropic CHAPS-PC bicelles with and without ganglioside GM1 using solution state NMR spectroscopy. In aqueous solution the peptide is predominately unstructured. In the presence of bicelle overall structure of the peptide is stabilized. In CHAPS-PC bicelle neurotensin adopts 3(10) helical structure. In the presence of GM1 containing bicelle, the peptide adopts predominately 3(10) helical structures with small amount of alpha-helical structure. These results are consistent with the CD spectroscopic results. Neurotensin interacts better with GM1 containing bicelle than that of the CHAPS-PC bicelle. Docking studies between the Neurotensin Receptor3 (NTS3) and different NT conformations also indicated better binding of the NT conformation obtained in presence of GM1-containing bicelles.

Modulation of the neurotensin solution structure in the presence of ganglioside GM1 bicelle.,Khatun UL, Goswami SK, Mukhopadhyay C Biophys Chem. 2012 Jul;168-169:48-59. Epub 2012 Jul 2. PMID:22824320<ref>PMID:22824320</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2lnf" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Khatun U]]
[[Category: Mukhopadhyay C]]