View source for 2lp3


==Solution structure of S100A1 Ca2+==
<StructureSection load='2lp3' size='340' side='right'caption='[[2lp3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lp3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LP3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lp3 OCA], [https://pdbe.org/2lp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lp3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lp3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.

==See Also==
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Belczyk-Ciesielska A]]
[[Category: Bierzynski A]]
[[Category: Budzinska M]]
[[Category: Ejchart A]]
[[Category: Ruszczynska-Bartnik K]]