View source for 2lr1


==Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA==
<StructureSection load='2lr1' size='340' side='right'caption='[[2lr1]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LR1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr1 OCA], [https://pdbe.org/2lr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref> 

==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human herpesvirus 5 strain AD169]]
[[Category: Large Structures]]
[[Category: Ma J]]