View source for 2lsx


==Solution structure of a mini i-motif==
<StructureSection load='2lsx' size='340' side='right'caption='[[2lsx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lsx]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsx OCA], [https://pdbe.org/2lsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsx RCSB], [https://www.ebi.ac.uk/pdbsum/2lsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsx ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The repetitive DNA sequences found at telomeres and centromeres play a crucial role in the structure and function of eukaryotic chromosomes. This role may be related to the tendency observed in many repetitive DNAs to adopt non-canonical structures. Although there is an increasing recognition of the importance of DNA quadruplexes in chromosome biology, the co-existence of different quadruplex-forming elements in the same DNA structure is still a matter of debate. Here we report the structural study of the oligonucleotide d(TCGTTTCGT) and its cyclic analog d&lt;pTCGTTTCGTT&gt;. Both sequences form dimeric quadruplex structures consisting of a minimal i-motif capped, at both ends, by a slipped minor groove-aligned G:T:G:T tetrad. These mini i-motifs, which do not exhibit the characteristic CD spectra of other i-motif structures, can be observed at neutral pH, although they are more stable under acidic conditions. This finding is particularly relevant since these oligonucleotide sequences do not contain contiguous cytosines. Importantly, these structures resemble the loop moiety adopted by an 11-nucleotide fragment of the conserved centromeric protein B (CENP-B) box motif, which is the binding site for the CENP-B.

A minimal i-motif stabilized by minor groove G:T:G:T tetrads.,Escaja N, Viladoms J, Garavis M, Villasante A, Pedroso E, Gonzalez C Nucleic Acids Res. 2012 Oct 5. PMID:23042679<ref>PMID:23042679</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2lsx" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Escaja N]]
[[Category: Garavis M]]
[[Category: Gonzalez C]]
[[Category: Pedroso E]]
[[Category: Viladoms J]]
[[Category: Villasante A]]