View source for 2ltx


==Smurf1 WW2 domain in complex with a Smad7 derived peptide==
<StructureSection load='2ltx' size='340' side='right'caption='[[2ltx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ltx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltx OCA], [https://pdbe.org/2ltx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltx RCSB], [https://www.ebi.ac.uk/pdbsum/2ltx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SMUF1_HUMAN SMUF1_HUMAN] E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.<ref>PMID:10458166</ref> <ref>PMID:19937093</ref> <ref>PMID:21402695</ref> 

==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aragon E]]
[[Category: Gao S]]
[[Category: Goerner N]]
[[Category: Lopes T]]
[[Category: Macias MJ]]
[[Category: Massague J]]
[[Category: Xi Q]]