View source for 2lty


==NEDD4L WW2 domain in complex with a Smad7 derived peptide==
<StructureSection load='2lty' size='340' side='right'caption='[[2lty]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lty OCA], [https://pdbe.org/2lty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lty RCSB], [https://www.ebi.ac.uk/pdbsum/2lty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lty ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NED4L_HUMAN NED4L_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.<ref>PMID:12911626</ref> <ref>PMID:15217910</ref> <ref>PMID:15489223</ref> <ref>PMID:15040001</ref> <ref>PMID:15496141</ref> <ref>PMID:15576372</ref> <ref>PMID:19144635</ref> 

==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aragon E]]
[[Category: Gao S]]
[[Category: Goerner N]]
[[Category: Lopes T]]
[[Category: Macias MJ]]
[[Category: Massague J]]
[[Category: Xi Q]]