View source for 2lv9


==Solution NMR structure of the PHD domain of human MLL5, Northeast structural genomics consortium target HR6512A==
<StructureSection load='2lv9' size='340' side='right'caption='[[2lv9]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LV9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lv9 OCA], [https://pdbe.org/2lv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lv9 RCSB], [https://www.ebi.ac.uk/pdbsum/2lv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lv9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KMT2E_HUMAN KMT2E_HUMAN] Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.  Isoform NKp44L: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.

==See Also==
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Garcia M]]
[[Category: Houliston S]]
[[Category: Lemak A]]
[[Category: Min J]]
[[Category: Montelione GT]]
[[Category: Wu H]]
[[Category: Yee A]]