View source for 2lvn


==Structure of the gp78 CUE domain==
<StructureSection load='2lvn' size='340' side='right'caption='[[2lvn]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lvn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LVN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lvn OCA], [https://pdbe.org/2lvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lvn RCSB], [https://www.ebi.ac.uk/pdbsum/2lvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lvn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMFR_HUMAN AMFR_HUMAN] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref> 

==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Byrd RA]]
[[Category: Chen Y]]
[[Category: Das R]]
[[Category: Huang T]]
[[Category: King A]]
[[Category: Li J]]
[[Category: Liu S]]
[[Category: Tarasov SG]]
[[Category: Weissman AM]]