View source for 2lvr


==Solution structure of Miz-1 zinc finger 8==
<StructureSection load='2lvr' size='340' side='right'caption='[[2lvr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LVR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lvr OCA], [https://pdbe.org/2lvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lvr RCSB], [https://www.ebi.ac.uk/pdbsum/2lvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lvr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZBT17_HUMAN ZBT17_HUMAN] Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.<ref>PMID:9312026</ref> <ref>PMID:9308237</ref> <ref>PMID:19164764</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Beaulieu M]]
[[Category: Bedard M]]
[[Category: Bernard D]]
[[Category: Lavigne P]]
[[Category: Maltais L]]