View source for 2lvv


==NMR structure of TB24==
<StructureSection load='2lvv' size='340' side='right'caption='[[2lvv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LVV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lvv OCA], [https://pdbe.org/2lvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lvv RCSB], [https://www.ebi.ac.uk/pdbsum/2lvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lvv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FCA2_TRYBB FCA2_TRYBB] May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.
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== Publication Abstract from PubMed ==
Flagellar calcium binding proteins are expressed in a variety of trypanosomes and are potential drug targets for Chagas disease and African sleeping sickness. The flagellar calcium binding protein calflagin of Trypanosoma brucei (called Tb24) is a myristoylated and palmitoylated EF-hand protein that is targeted to the inner leaflet of the flagellar membrane. The Tb24 protein may also interact with proteins on the membrane surface that may be different from those bound to flagellar calcium binding proteins (FCaBPs) in T. cruzi. We report here the NMR structure of Tb24 that contains four EF-hand motifs bundled in a compact arrangement, similar to the overall fold of T. cruzi FCaBP (RMSD = 1.0 A). A cluster of basic residues (K22, K25, K31, R36, and R38) located on a surface near the N-terminal myristoyl group may be important for membrane binding. Non-conserved residues on the surface of a hydrophobic groove formed by EF2 (P91, Q95, D103, and V108) and EF4 (C194, T198, K199, Q202, and V203) may serve as a target protein binding site and could have implications for membrane target recognition.

NMR structure of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.,Xu X, Olson CL, Engman DM, Ames JB Protein Sci. 2012 Sep 25. doi: 10.1002/pro.2167. PMID:23011904<ref>PMID:23011904</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Ames J]]