View source for 2lw7


==NMR solution structure of human HisRS splice variant==
<StructureSection load='2lw7' size='340' side='right'caption='[[2lw7]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lw7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LW7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lw7 OCA], [https://pdbe.org/2lw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lw7 RCSB], [https://www.ebi.ac.uk/pdbsum/2lw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lw7 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Usher syndrome type 3;Autosomal dominant Charcot-Marie-Tooth disease type 2W. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/HARS1_HUMAN HARS1_HUMAN] Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).<ref>PMID:26072516</ref> <ref>PMID:29235198</ref> 

==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Schimmel P]]
[[Category: Wei Z]]
[[Category: Wu J]]
[[Category: Ye F]]
[[Category: Zhang M]]