View source for 2lxu


==Solution NMR Structure of the eukaryotic RNA recognition motif, RRM1, from the heterogeneous nuclear ribonucleoprotein H from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8614A==
<StructureSection load='2lxu' size='340' side='right'caption='[[2lxu]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxu OCA], [https://pdbe.org/2lxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxu RCSB], [https://www.ebi.ac.uk/pdbsum/2lxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxu ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HNRH1_HUMAN HNRH1_HUMAN] Precursor T-cell acute lymphoblastic leukemia. 
== Function ==
[https://www.uniprot.org/uniprot/HNRH1_HUMAN HNRH1_HUMAN] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).<ref>PMID:11003644</ref> <ref>PMID:16946708</ref> 

==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Acton TB]]
[[Category: Everett JK]]
[[Category: Janjua H]]
[[Category: Kennedy MA]]
[[Category: Kohan E]]
[[Category: Montelione GT]]
[[Category: Pederson K]]
[[Category: Prestegard JH]]
[[Category: Ramelot TA]]
[[Category: Shastry R]]
[[Category: Xiao R]]
[[Category: Yang Y]]