View source for 2lyf


==High resolution NMR solution structure of the theta-defensin RTD-1==
<StructureSection load='2lyf' size='340' side='right'caption='[[2lyf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lyf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LYF FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyf OCA], [https://pdbe.org/2lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyf RCSB], [https://www.ebi.ac.uk/pdbsum/2lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyf ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The theta-defensins are, to date, the only known ribosomally synthesized cyclic peptides in mammals, and they have promising antimicrobial bioactivities. The characteristic structural motif of the theta-defensins is the cyclic cystine ladder, comprising a cyclic peptide backbone and three parallel disulfide bonds. In contrast to the cyclic cystine knot, which characterizes the plant cyclotides, the cyclic cystine ladder has not been as well described as a structural motif. Here we report the solution structures and nuclear magnetic resonance relaxation properties in aqueous solution of three representative theta-defensins from different species. Our data suggest that the theta-defensins are more rigid and structurally defined than previously thought. In addition, all three theta-defensins were found to self-associate in aqueous solution in a concentration-dependent and reversible manner, a property that might have a role in their mechanism of action. The structural definition of the theta-defensins and the cyclic cystine ladder will help to guide exploitation of these molecules as structural frameworks for the design of peptide drugs.

Structural Characterization of the Cyclic Cystine Ladder Motif of theta-Defensins.,Conibear AC, Rosengren KJ, Harvey PJ, Craik DJ Biochemistry. 2012 Nov 20. PMID:23148585<ref>PMID:23148585</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Conibear AC]]
[[Category: Craik DJ]]
[[Category: Harvey PJ]]
[[Category: Rosengren K]]