View source for 2m52


==NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2==
<StructureSection load='2m52' size='340' side='right'caption='[[2m52]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2m52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M52 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m52 OCA], [https://pdbe.org/2m52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m52 RCSB], [https://www.ebi.ac.uk/pdbsum/2m52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m52 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/U2AF2_MOUSE U2AF2_MOUSE] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Dutta SK]]
[[Category: Geralt M]]
[[Category: Serrano P]]
[[Category: Wuthrich K]]