View source for 2mbv


==LMO4-LIM2 in complex with DEAF1 (404-418)==
<StructureSection load='2mbv' size='340' side='right'caption='[[2mbv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbv OCA], [https://pdbe.org/2mbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbv RCSB], [https://www.ebi.ac.uk/pdbsum/2mbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LMO4_MOUSE LMO4_MOUSE] Probable transcriptional factor.[https://www.uniprot.org/uniprot/DEAF1_MOUSE DEAF1_MOUSE] Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3 (By similarity). May also involved in behavior (PubMed:24726472).[UniProtKB:O75398]<ref>PMID:14966286</ref> <ref>PMID:18826651</ref> <ref>PMID:19668219</ref> <ref>PMID:24726472</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Cubeddu L]]
[[Category: Foo P]]
[[Category: Joseph S]]
[[Category: Kwan AH-Y]]
[[Category: Mackay JP]]
[[Category: Matthews JM]]