View source for 2mdk


==NMR Solution Structure of MSP-P56S Domain/VAPB in DPC==
<StructureSection load='2mdk' size='340' side='right'caption='[[2mdk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdk OCA], [https://pdbe.org/2mdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mdk RCSB], [https://www.ebi.ac.uk/pdbsum/2mdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdk ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN] Adult-onset proximal spinal muscular atrophy, autosomal dominant;Amyotrophic lateral sclerosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/VAPB_HUMAN VAPB_HUMAN] Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.<ref>PMID:16891305</ref> <ref>PMID:20940299</ref> <ref>PMID:22131369</ref> 

==See Also==
*[[Vesicle-associated membrane protein 3D structures|Vesicle-associated membrane protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lim L]]
[[Category: Qin H]]
[[Category: Song J]]