View source for 2mfp


==Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1==
<StructureSection load='2mfp' size='340' side='right'caption='[[2mfp]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MFP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mfp OCA], [https://pdbe.org/2mfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mfp RCSB], [https://www.ebi.ac.uk/pdbsum/2mfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mfp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EC1_WHEAT EC1_WHEAT] Binds 5 molecules of zinc. May have a role in Zn(2+) homeostasis during embryogenesis.
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== Publication Abstract from PubMed ==
The first cyclic analog of a metallothionein (MT) was prepared and analyzed by UV and (magnetic) circular dichroism spectroscopy, ESI-MS as well as NMR spectroscopy. Results reveal that the evaluated cyclic g-Ec-1 domain of the wheat MT Ec-1 retains its ability to coordinate two Zn(II) or Cd(II) ions and adopts a three-dimensional structure that is highly similar to the one of the linear wild-type form. However, the reduced flexibility of the protein backbone facilitates structure solution significantly and results in a certain stabilization of metal binding to the protein.

Solution Structure of the Circular gamma-Domain Analog from the Wheat Metallothionein Ec-1.,Tarasava K, Johannsen S, Freisinger E Molecules. 2013 Nov 21;18(11):14414-29. doi: 10.3390/molecules181114414. PMID:24284492<ref>PMID:24284492</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2mfp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Triticum aestivum]]
[[Category: Freisinger E]]
[[Category: Johannsen S]]
[[Category: Tarasava K]]