View source for 2mio


==Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A==
<StructureSection load='2mio' size='340' side='right'caption='[[2mio]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mio OCA], [https://pdbe.org/2mio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mio RCSB], [https://www.ebi.ac.uk/pdbsum/2mio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mio ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHG10_HUMAN RHG10_HUMAN] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

==See Also==
*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Eletsky A]]
[[Category: Everett JK]]
[[Category: Janjua H]]
[[Category: Montelione GT]]
[[Category: Pulavarti SVSRK]]
[[Category: Sukumaran DK]]
[[Category: Szyperski T]]
[[Category: Wang H]]
[[Category: Xiao R]]
[[Category: Xu X]]