View source for 2mj7


==Solution NMR structure of beta-adaptin appendage domain of human adaptor protein complex 4 subunit beta, Northeast Structural Genomics Consortium (NESG) Target HR8998C==
<StructureSection load='2mj7' size='340' side='right'caption='[[2mj7]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mj7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJ7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj7 OCA], [https://pdbe.org/2mj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj7 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj7 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/AP4B1_HUMAN AP4B1_HUMAN] Severe intellectual deficit and progressive spastic paraplegia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/AP4B1_HUMAN AP4B1_HUMAN] Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

==See Also==
*[[Adaptin 3D structures|Adaptin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Eletsky A]]
[[Category: Everett JK]]
[[Category: Janjua H]]
[[Category: Maglaqui M]]
[[Category: Montelione GT]]
[[Category: Pederson K]]
[[Category: Prestegard JH]]
[[Category: Rotshteyn DJ]]
[[Category: Shastry R]]
[[Category: Szyperski T]]
[[Category: Xiao R]]