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==A tetrahelical DNA fold adopted by alternating GGG and GCG tracts==
<StructureSection load='2mjj' size='340' side='right'caption='[[2mjj]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mjj]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjj OCA], [https://pdbe.org/2mjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjj RCSB], [https://www.ebi.ac.uk/pdbsum/2mjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjj ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
DNA can form diverse higher-order structures, whose details are greatly dependent on nucleotide sequence. G-rich sequences containing four or more repeats of three guanines are expected to form G-quadruplexes. Here we show that DNA sequences with GGGAGCG repeats found in the regulatory region of the PLEKHG3 gene are capable of forming tetrahelical DNA structures that are distinct from G-quadruplexes. The d(GGGAGCGAGGGAGCG) sequence, VK1, forms a dimer. Two VK1 sequences connected by an adenine residue, VK2, fold into a monomer, which shares identical structural characteristics with the VK1 fold. Their four-stranded architectures are stabilized by four G-C, four G-A and six G-G base pairs. No G-quartets or Hoogsteen-type hydrogen-bonded guanine residues are present and the overall topology is conserved in the presence of Li(+), Na(+), K(+) and NH4(+) ions. Unique structural features include two edgewise loops on each side of the structure stabilized by three G-G base pairs in N1-carbonyl symmetric geometry.

A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts.,Kocman V, Plavec J Nat Commun. 2014 Dec 15;5:5831. doi: 10.1038/ncomms6831. PMID:25500730<ref>PMID:25500730</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Kocman V]]
[[Category: Plavec J]]