View source for 2mjx


==Solution NMR structure of a mismatch DNA==
<StructureSection load='2mjx' size='340' side='right'caption='[[2mjx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mjx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjx OCA], [https://pdbe.org/2mjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjx RCSB], [https://www.ebi.ac.uk/pdbsum/2mjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjx ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mutations in the genome are responsible for several fatal genetic disorders. The default DNA repair mechanism restores the malfunction of the gene caused by mutation to maintain functional regularity and sequential integrity of the cell. Here, we have elucidated the NMR structure and the dynamics of GC mismatched DNA (PDB code: 2MJX) and found that the mismatched DNA still retains the typical B-type helical form, but in the process introduces backbone distortion resulting from frame-shifted base pairs.

Double GC:GC mismatch in dsDNA enhances local dynamics retaining the DNA footprint: a high-resolution NMR study.,Ghosh A, Kar RK, Krishnamoorthy J, Chatterjee S, Bhunia A ChemMedChem. 2014 Sep;9(9):2059-64. doi: 10.1002/cmdc.201402238. Epub 2014 Jul, 30. PMID:25080019<ref>PMID:25080019</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mjx" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Bhunia A]]
[[Category: Chatterjee S]]
[[Category: Ghosh A]]
[[Category: Kumar KR]]