View source for 2mjy


==Solution structure of synthetic Mamba-1 peptide==
<StructureSection load='2mjy' size='340' side='right'caption='[[2mjy]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjy OCA], [https://pdbe.org/2mjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjy RCSB], [https://www.ebi.ac.uk/pdbsum/2mjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3SX1_DENPO 3SX1_DENPO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
An efficient one-pot chemical synthesis of snake venom toxin Mambalgin-1 was achieved using an azide-switch strategy combined with hydrazide-based native chemical ligation. Synthetic Mambalgin-1 exhibited a well-defined structure after sequential folding in vitro. NMR spectroscopy revealed a three-finger toxin family structure, and the synthetic toxin inhibited human acid-sensing ion channel 1a.

One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1.,Pan M, He Y, Wen M, Wu F, Sun D, Li S, Zhang L, Li Y, Tian C Chem Commun (Camb). 2014 Jun 4;50(44):5837-9. doi: 10.1039/c4cc00779d. PMID:24619065<ref>PMID:24619065</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mjy" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dendroaspis polylepis polylepis]]
[[Category: Large Structures]]
[[Category: He Y]]
[[Category: Tian C]]
[[Category: Wu F]]