View source for 2mkk


==Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA==
<StructureSection load='2mkk' size='340' side='right'caption='[[2mkk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkk OCA], [https://pdbe.org/2mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkk RCSB], [https://www.ebi.ac.uk/pdbsum/2mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Afroz T]]
[[Category: Allain FH-T]]
[[Category: Belloc E]]
[[Category: Boixet JG]]
[[Category: Mendez R]]
[[Category: Skrisovska L]]