View source for 2mn8


==NMR structure of a peptoid analogue of maculatin G15 containing cis-Nleu at position 13==
<StructureSection load='2mn8' size='340' side='right'caption='[[2mn8]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ranoidea_genimaculata Ranoidea genimaculata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MN8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4G:N-(2-METHYLPROPYL)GLYCINE'>I4G</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn8 OCA], [https://pdbe.org/2mn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2mn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mn8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCU11_RANGE MCU11_RANGE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The inclusion of peptoid monomers into antimicrobial peptides (AMPs) increases their proteolytic resistance, but introduces conformational flexibility (reduced hydrogen bonding ability and cis/trans isomerism). We here use NMR spectroscopy to answer how the insertion of a peptoid monomer influences the structure of a regular alpha-helical AMP upon interaction with a dodecyl phosphocholine (DPC) micelle. Insertion of [(2-methylpropyl)amino]acetic acid in maculatin-G15 shows that the structural change and conformational flexibility depends on the site of insertion. This is governed by the micelle interaction of the amphipathic helices flanking the peptoid monomer and the side chain properties of the peptoid and its preceding residue.

Structural features of peptoid-peptide hybrids in lipid-water interfaces.,Uggerhoj LE, Munk JK, Hansen PR, Guntert P, Wimmer R FEBS Lett. 2014 Aug 25;588(17):3291-7. doi: 10.1016/j.febslet.2014.07.016. Epub, 2014 Jul 22. PMID:25063337<ref>PMID:25063337</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mn8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ranoidea genimaculata]]
[[Category: Guentert P]]
[[Category: Uggerhoej LE]]
[[Category: Wimmer R]]