View source for 2mnq


==1H, 13C, and 15N Chemical Shift Assignments for Thymosin alpha 1==
<StructureSection load='2mnq' size='340' side='right'caption='[[2mnq]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MNQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mnq OCA], [https://pdbe.org/2mnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mnq RCSB], [https://www.ebi.ac.uk/pdbsum/2mnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mnq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTMA_HUMAN PTMA_HUMAN] Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
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== Publication Abstract from PubMed ==
Objective: Thymosin alpha1 (Talpha1) is a peptide hormone whose therapeutic application has been approved in several diseases, but the description of a precise receptor for its therapeutic action still remains elusive and some knowledge of the mechanism of interaction with the cell membrane still needs to be clarified. This work is aimed at studying the folding and interaction of Talpha1, which is completely unstructured in water solution, with model membranes. Methods: The folding and interaction of Talpha1 with sodium dodecyl sulfate micelles was monitored by NMR and CD spectroscopy techniques. Results: Talpha1 assumes a helical conformation in the presence of sodium dodecyl sulfate micelles, showing a helical fold with a structural break around residues 9 and 14. These results were confirmed by circular dichroism and NMR spectroscopy. Moreover, by paramagnetic NMR relaxation it was found that Talpha1 is inserted in the hydrophobic region of the micelles by the residues 1 - 5 of the N-terminal end. This result clarifies the modality of insertion that was not obtained in previous NMR studies in trifluoroethanol. Conclusions: These findings suggest that Talpha1 folds on the membrane and, when inserted, may be able to interact with nearby proteins and/or receptors acting as an effector and causing a biological signaling cascade.

Thymosin alpha1 inserts N terminus into model membranes assuming a helical conformation.,Nepravishta R, Mandaliti W, Eliseo T, Vallebona PS, Pica F, Garaci E, Paci M Expert Opin Biol Ther. 2015 Feb 2:1-11. PMID:25642593<ref>PMID:25642593</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mnq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Eliseo T]]
[[Category: Garaci E]]
[[Category: Mandaliti W]]
[[Category: Nepravishta R]]
[[Category: Paci M]]
[[Category: Pica F]]
[[Category: Sinibaldi Vallebona P]]