View source for 2mof


==Structural insights of TM domain of LAMP-2A in DPC micelles==
<StructureSection load='2mof' size='340' side='right'caption='[[2mof]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mof OCA], [https://pdbe.org/2mof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mof RCSB], [https://www.ebi.ac.uk/pdbsum/2mof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mof ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/LAMP2_HUMAN LAMP2_HUMAN] Glycogen storage disease due to LAMP-2 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/LAMP2_HUMAN LAMP2_HUMAN] Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.<ref>PMID:8407947</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rout A]]
[[Category: Tjandra N]]