View source for 2mrf


==NMR structure of the ubiquitin-binding zinc finger (UBZ) domain from human Rad18==
<StructureSection load='2mrf' size='340' side='right'caption='[[2mrf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MRF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mrf OCA], [https://pdbe.org/2mrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mrf RCSB], [https://www.ebi.ac.uk/pdbsum/2mrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mrf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAD18_HUMAN RAD18_HUMAN] E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.<ref>PMID:17108083</ref> <ref>PMID:21659603</ref> 

==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bezsonova I]]
[[Category: Korzhnev DM]]
[[Category: Rizzo AA]]
[[Category: Salerno PE]]