View source for 2mz1


==Solution structure of hnRNP C RRM in complex with 5'-UUUUC-3' RNA==
<StructureSection load='2mz1' size='340' side='right'caption='[[2mz1]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mz1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZ1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz1 OCA], [https://pdbe.org/2mz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mz1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mz1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HNRPC_HUMAN HNRPC_HUMAN] Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.<ref>PMID:8264621</ref> <ref>PMID:7567451</ref> <ref>PMID:12509468</ref> <ref>PMID:16010978</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Allain FH-T]]
[[Category: Cienikova Z]]
[[Category: Damberger FF]]
[[Category: Hall J]]
[[Category: Maris C]]