View source for 2mz3


==Phosphorylation of CB1Cannabinoid Receptor Fourth Intracellular Loop Pepducins: Effects on Structure and Function==
<StructureSection load='2mz3' size='340' side='right'caption='[[2mz3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mz3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZ3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz3 OCA], [https://pdbe.org/2mz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mz3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mz3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chandrashekaran I]]
[[Category: Cowsik S]]
[[Category: Eldeeb K]]
[[Category: Ganjiwale A]]
[[Category: Howlett A]]