View source for 2n23


==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the N-terminal activation domain of EKLF (TAD1)==
<StructureSection load='2n23' size='340' side='right'caption='[[2n23]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2n23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N23 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n23 OCA], [https://pdbe.org/2n23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n23 RCSB], [https://www.ebi.ac.uk/pdbsum/2n23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n23 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Arseneault G]]
[[Category: Lecoq L]]
[[Category: Morse T]]
[[Category: Omichinski J]]
[[Category: Raiola L]]