View source for 2n62


==ddFLN5+110==
<StructureSection load='2n62' size='340' side='right'caption='[[2n62]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2n62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N62 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n62 OCA], [https://pdbe.org/2n62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n62 RCSB], [https://www.ebi.ac.uk/pdbsum/2n62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n62 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GELA_DICDI GELA_DICDI] F-actin cross-linking protein.[https://www.uniprot.org/uniprot/SECM_ECOLI SECM_ECOLI] Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix that normally blocks secA translation initiation, derepressing the expression of secA. Translational pausing of secM at Pro-166 under secretion-limiting conditions increases the duration of the disruption and thus increases secA expression. This is controlled by interaction of the secM signal peptide with secA and the translocon, possibly by secA pulling the paused secM out of the ribosome. The arrest sequence (150-FXXXXWIXXXXGIRAGP-166) is sufficient to cause arrest of unrelated proteins. Elongation arrest can be alleviated by mutations in the 23S rRNA or in ribosomal protein L22.
__TOC__
</StructureSection>
[[Category: Dictyostelium discoideum]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Cabrita LD]]
[[Category: Camilloni C]]
[[Category: Cassaignau AME]]
[[Category: Christodoulou J]]
[[Category: Dobson CM]]
[[Category: Launay HMM]]
[[Category: Robertson AL]]
[[Category: Vendruscolo M]]
[[Category: Wang X]]
[[Category: Waudby CA]]
[[Category: Wentink AS]]
[[Category: Wlodarski T]]