View source for 2ncz


==Solution NMR structures of BRD4 ET domain in complex with NSD3_1 peptide==
<StructureSection load='2ncz' size='340' side='right'caption='[[2ncz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ncz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NCZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ncz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ncz OCA], [https://pdbe.org/2ncz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ncz RCSB], [https://www.ebi.ac.uk/pdbsum/2ncz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ncz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Zeng L]]
[[Category: Zhou M]]