View source for 2ndm


==NMR solution structure of PawS Derived Peptide 21 (PDP-21)==
<StructureSection load='2ndm' size='340' side='right'caption='[[2ndm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ndm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zinnia_haageana Zinnia haageana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndm OCA], [https://pdbe.org/2ndm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndm RCSB], [https://www.ebi.ac.uk/pdbsum/2ndm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A1C7D043_9ASTR A0A1C7D043_9ASTR] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A new family of small plant peptides was recently described and found to be widespread throughout the Millereae and Heliantheae tribes of the sunflower family Asteraceae. These peptides originate from the post-translational processing of unusual seed-storage albumin genes, and have been termed PawS-derived peptides (PDPs). The prototypic family member is a 14-residue cyclic peptide with potent trypsin inhibitory activity named SunFlower Trypsin Inhibitor (SFTI-1). In this study we present the features of three new PDPs discovered in the seeds of the sunflower species Zinnia haageana by a combination of de novo transcriptomics and liquid chromatography-mass spectrometry. Two-dimensional solution NMR spectroscopy was used to elucidate their structural characteristics. All three Z. haageana peptides have well-defined folds with a head-to-tail cyclized peptide backbone and a single disulfide bond. Although two possess an anti-parallel beta-sheet structure, like SFTI-1, the Z. haageana peptide PDP-21 has a more irregular backbone structure. Despite structural similarities with SFTI-1, PDP-20 was not able to inhibit trypsin, thus the functional roles of these peptides is yet to be discovered. Defining the structural features of the small cyclic peptides found in the sunflower family will be useful for guiding the exploitation of these peptides as scaffolds for grafting and protein engineering applications.

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).,Franke B, Jayasena AS, Fisher MF, Swedberg JE, Taylor NL, Mylne JS, Rosengren KJ Biopolymers. 2016 Nov;106(6):806-817. doi: 10.1002/bip.22901. PMID:27352920<ref>PMID:27352920</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2ndm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Zinnia haageana]]
[[Category: Fisher MF]]
[[Category: Franke B]]
[[Category: Jayasena AS]]
[[Category: Mylne JS]]
[[Category: Rosengren K]]
[[Category: Swedberg JE]]
[[Category: Taylor NL]]