View source for 2o2v


==Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)==
<StructureSection load='2o2v' size='340' side='right'caption='[[2o2v]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2o2v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2v OCA], [https://pdbe.org/2o2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2v RCSB], [https://www.ebi.ac.uk/pdbsum/2o2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref> 

==See Also==
*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Edwards A]]
[[Category: Filippakopoulos P]]
[[Category: Knapp S]]
[[Category: Savitsky P]]
[[Category: Sundstrom M]]
[[Category: Ugochukwu E]]
[[Category: Von Delft F]]