View source for 2qhl


==Crystal Structure of Novel Immune-Type Receptor 10 Extracellular Fragment from Ictalurus punctatus==
<StructureSection load='2qhl' size='340' side='right'caption='[[2qhl]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qhl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ictalurus_punctatus Ictalurus punctatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QHL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhl OCA], [https://pdbe.org/2qhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qhl RCSB], [https://www.ebi.ac.uk/pdbsum/2qhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qhl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8UWK5_ICTPU Q8UWK5_ICTPU] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qh/2qhl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qhl ConSurf].
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== Publication Abstract from PubMed ==
Novel immune-type receptors (NITRs) comprise an exceptionally large, diversified family of activating and inhibitory receptors that has been identified in bony fish. Here, we characterized the structure of an activating NITR that is expressed by a cytotoxic natural killer (NK)-like cell line and that specifically binds an allogeneic B cell target. A single amino acid residue within the NITR immunoglobulin variable (V)-type domain accounts for specificity of the interaction. Structures solved by X-ray crystallography revealed that the V-type domains of NITRs form homodimers resembling rearranging antigen-binding receptor heterodimers. CDR1 elements of both subunits of NITR dimers form ligand-binding surfaces that determine specificity for the nonself target. In the evolution of immune function, it appears that a specific NK type of innate recognition may be mediated by a complex germline multigene family of V structures resembling those that are somatically diversified in adaptive immunological responses.

A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.,Cannon JP, Haire RN, Magis AT, Eason DD, Winfrey KN, Hernandez Prada JA, Bailey KM, Jakoncic J, Litman GW, Ostrov DA Immunity. 2008 Aug 15;29(2):228-37. Epub 2008 Jul 31. PMID:18674935<ref>PMID:18674935</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ictalurus punctatus]]
[[Category: Large Structures]]
[[Category: Bailey KM]]
[[Category: Cannon JP]]
[[Category: Haire RN]]
[[Category: Hernandez Prada JA]]
[[Category: Litman GW]]
[[Category: Magis AT]]
[[Category: Ostrov DA]]