View source for 2roo


==Solution structure of Magi4, a spider toxin from Macrothele gigas==
<StructureSection load='2roo' size='340' side='right'caption='[[2roo]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2roo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrothele_gigas Macrothele gigas]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2roo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2roo OCA], [https://pdbe.org/2roo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2roo RCSB], [https://www.ebi.ac.uk/pdbsum/2roo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2roo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TXMG4_MACGS TXMG4_MACGS] Selectively slows channel inactivation of mammalian Nav1.1/SCN1A, Nav1.3/SCN3A, and Nav1.6/SCN8A and shows higher affinity for insect Nav1/para channels (site 3). Induces tonic repetitive firing of nerve impulses in insect neurons accompanied by plateau potentials.<ref>PMID:12860384</ref> <ref>PMID:19592486</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Macrothele gigas]]
[[Category: Yamaji N]]